Unlike traditional target-based screens e.g. assessing enzyme or binding activity, zebrafish drug screening is a whole organism phenotype-based screen. Thus zebrafish screening can probe the entire pathway involved in a particular disease and can screen simultaneously for multiple targets and mechanisms. This makes zebrafish an excellent screening tool for complex diseases or diseases with unclear causes. After the screening, follow-up studies will define a drugs mechanism of action and elucidate its potential drug targets.
· High throughput drug screening:
Juvenile Zebrafish and embryos can be arranged in 96-well microplates for high-throughput drug screening, including drug efficacy detection and behavioral analysis.
·Drug toxicity assessment:
Developing zebrafish embryos and juveniles are transparent and the developing organs can be easily observed under a microscope. This allows simultaneous measurement of drug efficacy and toxicity, including developmental , cardiovascular , and neuro-toxicity.
· One stop service:
ZebraPeutics integrates upstream and downstream industry chain resources to provide one-stop service, including the construction of zebrafish disease models, high-throughput drug screening, efficacy verification and optimization of drug molecular structures, initial screening of drug toxicity, and research on a drugs molecular mechanisms of action.
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